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ROS can induce mutations in the BRCA1 gene, which is involved in DNA repair, leading to impaired DNA damage response and increased susceptibility to tumorigenesis [100]

The intrinsic pathway (mitochondrial pathway) involves two primary mechanisms of apoptosis: cytochrome c (Cyt C) release and the opening of the mitochondrial permeability transition pore (MPTP) (Taneja et al., 2001)

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