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Interestingly, a subset of neuronal storage disorders with increased levels of GM2 ganglioside result in the reinitiation of ectopic dendrites that form connections on mature neurons in the cortex (Siegel et al., 2002), suggesting that molecular cues exist that control dendrite initiation separately from axon initiation and dysregulation of such mechanisms could have pathological consequences (Cox and Cachon-Gonzalez, Dendritic synapses In the hippocampus and cortex, the majority of excitatory synapses are formed on spines while inhibitory synapses are predominantly formed on the cell bodies and dendritic shafts

Katakam, P

Kalinina EV, Chernov NN, Novichkova MD

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This oxidative imbalance might stabilize and activate NRF2 by disrupting its KEAP1-mediated degradation ( de novo GSH synthesis ( The PARK7 gene, which encodes the DJ-1 protein, is a causative gene for autosomal recessive early-onset Parkinsons disease ( 2.3 CHAC1 and ferroptosis Programmed cell death is an actively regulated process, governed by a complex network of genes and proteins, that is critical for normal physiological functions across organisms (La Marca et al., 2024)