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Emerging lines of evidence indicate that E3 exerts a critical regulatory function in oxidative stress homeostasis, primarily through the transcriptional upregulation of pivotal antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx)

First, the present study was designed in a cross-sectional manner

The samples were preirradiated for about 30 min at a low magnification to stabilize the sample and minimize contamination

Targeting these mitochondrial dependencies has emerged as a promising therapeutic strategy in CRc [6]

Activation of those genes, in turn, has been shown to extend the lifespan in a wide variety of organisms and to reduce the incidence of age-related diseases, such as diabetes, cancer, immune deficiencies, and cardiovascular disorders (Bordone and Guarente 2005)