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Give or take 5 pounds for large or small frame size respectively

Both modifications reduce binding protein affinity

doi: 10.3389/fncel.2016.00229 140 IzzoN

doi: 10.1186/1742-9994-10-33 17 BhardwajNKumarAGuptaNJ

Patients with a calculated clearance above 0.627 L/day were more likely to require colectomy at 6 months compared to those with lower clearance (61.5% vs