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While senescence acts as a protective mechanism against tumorigenesis, the accumulation of senescent cells and their inflammatory SASP can promote tumor progression

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While current treatments provide symptomatic relief, a disease-modifying therapy remains an unmet need

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Patients should be advised to report to the physician immediately any of the following: numbness or tingling in the fingers and toes, muscle pain in the arms and legs, weakness in the legs, pain in the chest, temporary speeding or slowing of the heart rate, swelling, or itching