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2011) SOD-catalyzed conversion of superoxide to oxygen and hydrogen peroxide by disproportionation is accomplished in two main steps: M 3+ + O 2 + H + M 2+ (H + ) + O 2 M 2+ (H + ) + H + + O 2 M 3+ + H 2 O 2 M represents the metal cofactor, M 3+ represents the highest valence of the metal cofactor, and M 2+ represents the valence of the metal cofactor after oxidation