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440 , 443 However, due to the complexity of the intestinal microbiota, FMT therapies are still highly heterogeneous with respect to donor selection, material preparation, ideal dosing regimen, and costeffectiveness, and are still a long way from clinical application

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G protein-coupled receptor (GPCR) is a 7-transmembrane protein receptor containing a G protein-binding region in the cytoplasm and a ligand-binding region outside the cell