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The role of necroptosis in coronary microvascular obstruction and the no-reflow phenomenon also needs to be studied

Collectively, these mechanisms translate into improvements in steatosis, lobular inflammation, and fibrosis in both experimental models and selected clinical trials, supporting their role as adjuncts to first-line lifestyle interventions

10.1378/chest.109.4.1006 91 HowladerS.KimM.-J.JonyM

doi: 10.3390/nu14102067 9 ReygaertWC

Glossary AKT/PKB protein kinase B ALS amyotrophic lateral sclerosis AMPK 5 adenosine monophosphate-activated protein kinase AP-1 activator protein-1 ATP adenosine triphosphate BACE1 -site amyloid precursor proteincleaving enzyme 1 BAG Bcl-2 associated athanogene family protein BBB bloodbrain barrier CASA chaperone-assisted selective autophagy CDK1 cyclin-dependent kinase 1 CHIP C-terminus HSC70-interacting protein CMA chaperone-mediated autophagy CSN constitutive photomorphogenesis 9 signalosomes eIF3 eukaryotic initiation factor 3 eNOS endothelial NO synthase ER endoplasmic reticulum FAF1 FAS-associated factor 1 FIC cell filamentation proteins FUS fused in sarcoma protein GF glycine/phenylalanine-rich region of HSP40 GPX4 glutathione peroxidase 4 GRP-E Gro-P like protein E GRP78/BiP glucose-regulated protein 78/binding immunoglobulin protein (HSPA5) HOP HSP70/HSP90 organizing protein HSC70 heat shock cognate protein (HSPA8) HSF1 heat shock factor 1 HSP40 (eukaryotes)/DNAJ (prokaryotes) 40-kDa heat shock protein family HSP70/HSPA (eukaryotes)/DNAK (prokaryotes) 70 kDa heat shock protein family IGFR insulin-like growth factor receptor IRE1 inositol-requiring endoribonuclease 1 KEAP1 kelch-like enoyl-coenzyme A hydratase-associated protein 1 KO knockout LAMP2A lysosome-associated membrane protein 2A LC3 microtubule-associated protein 1A/1B-light chain 3 MAPK mitogen-activated protein kinase MMP-2 matrix metalloproteinase-2 mTOR mechanistic/mammalian target of rapamycin kinase NBD nucleotide-binding domain, N-terminus NEF nucleotide exchange factor NF-B nuclear factor-B NRF2 nuclear factor erythroid 2-related factor 2 p97/VCP valosin-containing protein PERK protein kinase RNA-like endoplasmic reticulum kinase PGC1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha PI3K phosphatidylinositol 3-kinase PQC protein quality control PRRs pattern recognition receptors RNA ribonucleic acid ROS reactive oxygen species SBD substrate-binding domain SCF S-phase kinase-associated protein 1/cullin 1/F-box protein SERCA sarcoplasmic reticulum Ca 2+ -ATPase SIRT1 sirtuin 1, silent information regulator 1 SOD1 superoxide dismutase 1 TARDBP transactive response DNA binding protein 43 kDa TAX1BP1 Tax1-binding protein 1 TCAIM T-cell activation inhibitor in mitochondria TDP-43 transactive response DNA binding protein of 43 kDa UPRER unfolded protein response in the endoplasmic reticulum UPS ubiquitinproteasome system YBX1 Y-box binding protein 1 References 1 AcquaroneD.BerteroA.BrancaccioM.SorgeM