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Synthesis of hemiprotonic phenanthroline-phenanthroline(+) compounds with both antitumor and antimicrobial activity

B-017 inhibits apoptotic and necrotic signalling pathways in human cells To gain insight into the inhibitory effects of B-017, we examined its impact on cell death signalling in several mouse and human cell lines

With 100 mg/mL, 0.5 mL = 50 mg (100 mg 0.5 mL = 50 mg )

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Chromatographic purification of active metabolites All six extracts were air-dried and their residues were then resuspended in methanol to be ready for applying onto thin layer chromatography (TLC) plate (10 10 cm Merck aluminum sheet, silica gel 60, layer thickness 0.2 mm)