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GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues

doi: 10.1152/physrev.00040.2012

While ROS scavenging is beneficial in chronic diseases like diabetes (Zhang et al., 2020), excessive antioxidant supplementation may disrupt redox homeostasis, as evidenced by increased cancer risk in vitamin E trials (Poprac et al., 2017)

The consequences of recurrent hypoglycemic episodes include acute and long-term cognitive changes, arrhythmia and myocardial infarction, severe falls, weakness, and death