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One of the primary obstacles in the treatment of neurodegenerative diseases is the limited transport of large molecules into the brain due to the BBB

When combined with fibroblast growth factors (FGFs), which bind to receptors in the presence of heparin, causing endothelial cell migration, VEGF-A levels increase, leading to stabilization and growth of new vessels (Claire and Larrive 2017

Hence the steady-state divalproex-ER concentration-time profiles have small peak-trough fluctuations that are not optimally characterised by valproic acid elimination half-life

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