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In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different

For children with Crohns, this can cause a reduction in the expected rate of growth

Extensive laboratory and pre-clinical studies have reported that paracetamol off-label applications may be derived from its ability to function as an antioxidant (57, 58)

He had to take four months off work with sick leave