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These key mediators can activate signal transduction cascades as well as induce changes in transcription factors, such as nuclear factor kappa B (NF-B), signal transducer and activator of transcription 3 (STAT3), hypoxia-inducible factor-1 (HIF1-), activator protein-1 (AP-1), nuclear factor of activated T cells (NFAT) and NF-E2 related factor-2 (Nrf2), which mediate immediate cellular stress responses (Figure 2)

[730] The Commission noted that the limited resources of many safety-net hospitals may make it difficult for them to compete with other hospitals for labor and technology, and observed that [t]his disadvantage, in turn, could lead to difficulty maintaining quality of care and even to hospital closure. [731] During the earlier phases of the COVID-19 pandemic, for example, studies showed higher rates of mortality among patients who received treatment at certain safety-net hospitals, with researchers citing understaffing and lack of access to advanced therapies as some of the factors that may have contributed to negative health outcomes

Xiao X, Hou X, Shi W, Hu C, Cui Y, Hu J, Piao Z, Zhu X, Li Q, Xu F

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