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Ann Rev Immunol 27:119145 Riazi K, Galic MA, Kuzmiski JB, Ho W, Sharkey KA, Pittman QJ (2008) Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation

In ancient China, based on the experience of using medicinal botanical drugs, natural plants with medicinal properties were compiled into books such as Shennongs Classic of Materia Medica, Newly Revised Materia Medica, and Compendium of Materia Medica. Various plants were classified according to experience and used for targeted treatment of various diseases ( Gastrodia elata ) as an example, the earliest recorded pharmacological work on Tianma is in Shennongs Classic of Materia Medica. Over 2000 years ago, Tianma was already used for the treatment of cardiovascular, neurological, and nervous system diseases

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