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A more recent advance is mtDNA base editing, which utilizes engineered deaminase enzymes (e.g., DddA-derived cytosine base editors) to catalyze CG to TA base conversions in double-stranded mtDNA without creating double-strand breaks

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The His-Phe-Arg-Trp tetrapeptide core (positions 69) is preserved intact and has been identified as the pharmacophore responsible for melanocortin receptor activation