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From it protrude the ends of histone strands, which are the target of histone-modifying enzymes (see Fig

[PubMed] [Google Scholar] 61.Pirsch JD, Ploeg RJ, Gange S, DAlessandro AM, Knechtle SJ, Sollinger HW, et al

Shoal GD, Giancola PR, Kirillova GP (2003)

Hb oxidation also occurs as a natural process, resulting from RBC aging [33], that is associated with metabolic degradation due to reduction in enzyme activity