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Inflammation and NLRP3 inflammasome activation initiated in response to pressure overload by Ca(2+)/calmodulin-dependent protein kinase II signaling in cardiomyocytes are essential for adverse cardiac remodeling

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Patients with AH and AF had a higher in-hospital mortality rate (6.6%) compared to those without AF (5.2%) (adjusted odds ratio:1.29, 95% CI: 1.10-1.52, p=0.021)

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The strongest predictors are baseline IGF-1 level, age, sleep quality (7-9 hours nightly), training consistency (4-6 days/week), diet quality, and protocol adherence