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doi: 10.2337/db12-0495 19 SarabhaiTRodenM

MalagMMarchiniFFiorioASirugoPClSMariEet alAtrial fibrillation in -thalassemia: overview of mechanism, significance and clinical management

IFN- acts on the IFN- receptor, resulting in the phosphorylation of JAK1/2, which triggers the phosphorylation of STAT1 and leads to an increase in interferon regulatory factor 1 (IRF1) expression, which inhibits the function of SLC7A11 with SLC3A2 (system Xc ), ultimately leading to ferroptosis (61)