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Cells from myelodysplastic (MDS) and AML patients with TET2 mutation harbor more non-synonymous somatic mutations than TET2 wild-type patients, and HSPCs of Tet2 knockout mice also exhibit increased mutation rates (Pan et al., 2017)

(Malik et al., 2018) demonstrated that MenSC-derived hepatocyte progenitor-like cells more effectively improved liver injury markers compared to BM-MSCs, with greater reductions in inflammation, necrosis, and collagen deposition

Preclinical data highlight 3-5x efficacy gains, although clinical translation requires GSH gradient validation (143) (Figure 3)

[DOI] [PMC free article] [PubMed] [Google Scholar] 167.Korovila I., Hugo M., Castro J.P., Weber D., Hhn A., Grune T., Jung T

In this study, we dissect the catalytic cycle of Schistosoma mansoni TGR by structural and functional analysis of the U597C mutant