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Additionally, in TNF- -stimulated gastric cancer (AGS and MKN45) cells, triptolide enhances apoptosis via modulation of the H19/ miR-204-5p /NF- B/FLIP axis, suggesting that its ability to induce apoptosis is multifaceted and includes both the promotion of ROS generation and the regulation of specific signaling pathways [1010, 1011]