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Voltage-gated ion channels enable the selective influx and efflux of ions, such as sodium, potassium, and calcium, across the BBB, thereby contributing to the maintenance of electrochemical gradients [119]

The time taken by the mice to reach the floor with its four paws was recorded as locomotion activity time T-total and the time taken by the mice to turn completely head downward was recorded T-turn time

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Yue-Yu Gu, [email protected] These authors have contributed equally to this work This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Moayyedi P, Quigley EM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al