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Description

SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation

DNA torsion, and chromatin dynamics

For conditional MOR knockdown in PVN Glu neurons, we injected the rAAV-CMV-DIO-(EGFP-U6)-shRNA ( Oprm1 )-WPRE-hGH pA (AAV-DIO-shMOR-EGFP) virus or rAAV-CMV-DIO-(EGFP-U6)-shRNA(scramble)-WPRE-hGH polyA (AAV-DIO-EGFP) vector control into the bilateral PVN of VgluT2-Cre mice