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Researchers who initially published their findings in the late 1980s and early 1990s have since revised and expanded their theory to propose that the pineal gland and its secreted substances, which may include melatonin and possibly other compounds, serve as an internal control and regulatory mechanism for self-control

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When melanocytes produce and distribute melanin, this pigment is mainly transferred to keratinocytes which influence the skin tone

doi: 10.1016/j.ccr.2011.01.038 42 YaeTTsuchihashiKIshimotoTMotoharaTYoshikawaMYoshidaGJet al

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