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Although xCT-GPX4-GSH is considered to be the primary mechanism that prevents ferroptosis, inhibition of GPX4 or GPX4 knockout fails to trigger ferroptosis in certain cancer cell lines, suggesting alternative resistance mechanisms[79, 91-93]

[DOI] [PubMed] [Google Scholar] 48.Loureiro A.C.C., do Rgo-Monteiro I.C., Louzada R.A., Ortenzi V.H., de Aguiar A.P., de Abreu E.S., Cavalcanti-de-Albuquerque J.P.A., Hecht F., de Oliveira A.C., Ceccatto V.M., et al

Many human studies on BPC-157 have been canceled or stopped without publicly available conclusions, so there's still a lot we don't know about its long-term safety and efficacy

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