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Description

Ko E, Seo HW, Jung G

SystemXc- System Xc-, present in the phospholipid bilayer as a cystine/glutamate antiporter, is composed of the transporter solute carrier family 7 member 11 (SLC7 A11/xCT) and the regulatory subunit solute carrier family 3 member 2 (SLC3 A2)

A large amount of cystine is cytotoxic to cells in highly SLC7A11-expressing tumor cells, but the protective mechanism of the body can drive cells to rapidly reduce cystine to soluble Cys