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20 BiancoF.SalomoneF.MilesiI.MurgiaX.BonelliS.PasiniE.et al (2021)

When you take vitamins by mouth the absorption of nutrients from your stomach can be minimal

His and Arg act to help create the reactive environment, and Cys once again acts as the reaction center by using a thioester help hold a carboxyl group until the amine of a Lysine can perform a nucleophilic attack to transfer the protein and form the isopeptide bond