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Coenzyme Q10 (CoQ10), also referred to as ubiquinone, primarily facilitates electron transfer from complexes I and II to complex III in the mitochondrial electron transport chain

K., Renninger NS, Newman

Another possible explanation why ROS-scavenging by antioxidants did not restore the functionality of Gclc -deficient B cells is the altered redox state caused by this treatment

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However, efforts to demonstrate the clinical benefit of DUB inhibition have been hampered by the poor selectivity of early compounds, as well as a limited understanding of DUB biology, especially the scope of unique and shared substrates across the family of DUB enzymes