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Ce phnomne peut tre particulirement problmatique avec les mdicaments dits marge thrapeutique troite , cest--dire ceux pour lesquels un faible cart de dose ou de concentration peut suffire provoquer un effet excessif ou dangereux

However, by enhancing ferritinophagy through inhibition of cytosolic glutamate oxaloacetate transaminase 1 (GOT1), the level of labile iron pools increases, ultimately leading to ferroptosis [28] (Fig