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All EXOs from different cell types share a few groups of proteins (Vaiciuleviciute et al., 2025

Peripheral-blood exome, genome, and Sanger sequencing to identify pathologic mutations in SOD1 in 4000 patients with ALS from Germany, South Korea, and Sweden has revealed four sporadic ALS cases with de novo mutations in SOD1 , which might be the therapeutic target of ASO [170]

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