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The absence of pharmacokinetic or pharmacodynamic interaction studies means healthcare providers must rely on theoretical considerations and the known pharmacology of each component when patients inquire about combination use

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This underscores how microbiome alterations may both predispose individuals to stroke and influence recovery (Lee Y

A direct comparative analysis elucidates how these agents may be positioned rationally as adjunctive or alternative interventions depending on clinical phenotype, biological vulnerability, and therapeutic goals