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Alterations in the levels of long and medium chain acyl-carnitines, including octadecenoyl-carnitine (C18:1), tetradecenoyl-carnitine (C14:1), tetradecadienoyl-carnitine (C14:2) and short chain acyl-carnitines, such as malonyl-carnitine/hydroxybutyryl-carnitine (C3DC + C4OH), have been reported both in T2D and pre-diabetes states in serum 3,13,44,45

295 StewartJ

Phase 1B, randomized, double-blinded, dose escalation, single-center, repeat dose safety and pharmacodynamics study of the oral NLRP3 inhibitor dapansutrile in subjects with NYHA II-III systolic heart failure