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[ [PMID: 33525951] [ [PMID: 30345630] [ [PMID: 28002651] et al

Therefore, All patients treated with pemetrexed must be instructed to take folic acid and vitamin B12 as a prophylactic measure to reduce treatmentrelated toxicity

ALDH2 deficiency dramatically slows acetaldehyde conversion, producing toxic accumulation symptoms

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[9] Hydrochlorothiazide-induced fluctuations in serum electrolyte concentration can occur rapidly and precipitate hepatic coma in susceptible patients