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IFN- is essential to inducing broad, nonspecific resistance against viral infection by regulating the expression of multiple antiviral genes

doi: 10.1097/MEG.0b013e328318ed19 54

SARS-CoV-2 promotes distinct mitochondrial subpopulations that lack cristae or the ability to produce ATP Recent advances in mitochondrial bioenergetics reveal that mitochondria dynamically respond to nutrient deficiency by forming distinct subpopulations that either specialize in the production of ATP or macromolecular precursors that support cellular growth [390]

Metaxas C, Mathis D, Jeger C et al (2017) Early biomarker response and patient preferences to oral and intramuscular Vitamin B12 substitution in primary care: a randomized parallel-group trial