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It is clear now that kidney is not a mere target of insulin action, but insulin, more precisely IR, is also able to trigger CKD even in absence of diabetes

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5 extended data 1a), and their intended clinical application, we selected Sm5 (dyclonine) and Sm11 (leucovorin) as the best candidates to test their efficiency to promote oligodendrogenesis in pre-clinical models of myelin pathologies