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Collectively, these findings demonstrate that miR-335-5p directly binds to the 3-UTR of PRKAA2 and negatively regulates its expression

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By signaling downstream pathways, specifically mitogen-activated protein kinases/activator protein-1(MAPK/AP-1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), and Janus kinase-signal transducer and activator of transcription (JAKSTAT), excess ROS can effectively induce the production of inflammatory mediators, cytokines, and growth factors

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