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Bioavailability is key in determining how much of a drug reaches its target

The application time was either at 20 min after L-NAME administration (as early therapy) or at 48 h after L-NAME administration (as delayed therapy)

Thats because Hashimotos generally causes slow, subtle changes to the thyroid gland over the course of many years, which suggests that the TPO antibodies that characterize Hashimotos are not likely to be causing symptoms

Dosing interval also varies by age (Table 1)

This guarantees complete bioavailability of the full dose regardless of gut health, transporter saturation or individual digestive efficiency