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[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Yang G., Zhao K., Ju Y., et al

Glutaredoxin from calf thymus

Oxidative stress is triggered by the production of superoxide ions and hydrogen peroxide (Valencia-Olvera et al., 2014) in the former pathway

This is a conceptual argument rather than a measured one again, the human PK data do not exist but it illustrates why systemic delivery is not self-evidently advantageous for a cosmetic goal, and why the burden of proof sits squarely on anyone claiming injection is the better skin route