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That said, there are still some risks associated with supplementing vitamin B12 if you arent deficient: A 2015 study found that excess vitamin B12 is associated with acne and rosacea

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Noteworthy, as described above, there are significant time-varying arterio-venous differences in BAC (99), but the sampling of arterial, in contrast to venous blood, is challenging and poses an increased risk to study participants