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A growing number of studies indicate that patients with AD are deficient in vitamin A and susceptible to bacterial colonization by Staphylococcus aureus [35,36,37]

Moreover, the drugs can induce senescence in normal tissues in vivo that could play a negative role in tumor progression because the SASP pattern in tumor microenvironment stimulates cancer progression [23]

This limitation raises concerns regarding donor burden, scalability, and the feasibility of repeated clinical administration

doi: 10.3389/fimmu.2021.686501

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