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These tend to be most pronounced during the dose escalation period and generally improve over time

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For wound repair evaluation, a transparent acetate sheet (Sigma-Aldrich, St Louis, MO, USA) was placed on the wound, its perimeter was traced and then sheared along the wound tracing, and the sheared part was weighed

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As painful as it is to tell a patient we dont have a proven therapy, it is far worse to give false hope or possibly cause harm with an unvetted substance