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1 H NMR (300MHz, CDClj): 8.72 (s, 1 H), 8.15 (s, 1 H), 6.44 (s, 1 H), 4.79 (m, 1 H), 3.20 - 3.06 (m, 14H), 2.09 - 2.03 (m, 4H), 1.78 - 1.76 (m, 4H)

By activating the AMPK/SIRT1 pathway, metformin effectively regulates insulin resistance and improves hormonal status

Apoptosis operates through two distinct pathways: the intrinsic pathway, which is dependent on internal signaling, primarily regulated by the BCL-2 family of proteins and involves mitochondria interactions, and the extrinsic pathway, which is dependent of external signaling and independent of BCL-2 and mitochondrial involvement (Jan and Chaudhry, 2019)

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

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