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grant COSMIT 2015-0451), Brazilian National Counsel of Technological and Scientific Development (CnPQ), CAPES-COFECUB, CELLOMET and INSERM

Site-directed mutagenesis was performed using Phusion DNA polymerase (NEB)

This approach led to restoring p53 expression, sensitizing tumors to sirolimus, and strong antitumor effect in various preclinical HCC and NSCLC models (92)