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Another miRNA shown to regulate Nrf2 is miR-34, able not only to target NFE2L2 but also downstream genes involved in cellular response to OS, such as microsomal glutathione S-transferase 1 ( Mgst1 ) and Sirtuin 1 ( Sirt1 ) genes in rat liver during aging [226]

PD patients exhibit autoreactive T lymphocytes that identify particular -synuclein epitopes, indicating that loss of tolerance to neuronal antigens leads to persistent neuroinflammation