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Description

Hydroxyl groups on the support are employed in most covalent coupling methods

All of these elements contribute to the failure of experimental drug candidates in human trials

Following the completion of the reaction, the pH was adjusted to 7.5 by adding an aqueous solution of NaOH ( c = 0.25 M), before diluting the nucleotide solution to a total volume of 100 mL with milliQ H 2 O