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Inadequate perfusion in areas of rapid cell proliferation creates hypoxia and decreases the supply of nutrients including glucose

(Basel) 17 (1), 38

Second, while in vitro cell models offer high controllability for dissecting signaling pathways, they lack critical multi-organ interactionssuch as those along the gutliver axismaking it difficult to recapitulate the multi-target and systemic regulatory effects of hawthorn under physiological conditions