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Non-cell-autonomous mechanisms involving glial cells have emerged as significant contributors to pathology, particularly through their influence on neuroinflammation, proteostasis, and autophagy-dependent pathways [310,313]

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Antioxidant effects of statins by modulating Nrf2 and Nrf2/HO-1 signaling in different diseases

Specifically, they activate the AMPK/PPAR- signaling axis, which reduces fibroblast proliferation and myofibroblast differentiation in fibrotic models [197]