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[DOI] [PubMed] [Google Scholar] Fu Y, Zhou YJ, Lu SC, Chen AP

Cell 173 , 386399 (2018)

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Although initially activated to buffer metabolic stress, the PINK1-Parkin pathway becomes suppressed under chronic overload, such as prolonged palmitate exposure, resulting in dysfunctional mitochondria, heightened oxidative stress, and activation of the NLRP3 inflammasome