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8 Challenges and future directions 8.1 Heterogeneity in PC/Ferroptosis regulation A primary challenge impeding the broad clinical application of therapies targeting PC metabolism and ferroptosis is the profound heterogeneity that characterizes TME

The letter C is associated with the numbers to designate the cervical spine

In a study of 72 patients with OSF and 30 healthy individuals, the researchers identified OSF development associated with enrichment of Th17 cell and IL-17 infiltration occurred in the tissues and PBMCs of patients with OSF

Studies support a bi-directionality of causation between inflammation (vascular or otherwise) and CHIP, and as CH exacerbates insulin resistance in preclinical models (278, 279), the hypothesis that critical illnesses can drive CHIP must be taken seriously (280)

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