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Created using BioRender ( TGF- primarily binds to two receptor types found on all cell surfaces, transforming growth factor receptor I (TGFRI) and TGFRII, and activation of the TGF- receptors involves TGFRII binding to the TGF- ligand and recruiting TGFRI, causing the phosphorylation of TGFRI and subsequent phosphorylation of signal transduction proteins SMAD2 and SMAD3