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At the age of 9.38 years (Table 1), an increase of LH levels (3.38 mUI/L) and a simultaneous decrease of height velocity (-0.9 SDS, height 136 cm) were recorded

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Thus, ER stress-induced CHAC1 expression depletes GSH, compromises GPX4 function, and promotes ferroptotic cell death ( 4.5.3 Possible role of methionine Prolonged methionine deprivation blocks CHAC1 protein synthesis by interfering with its translation, thereby inhibiting ferroptosis